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    <title>Simcyp Posters RSS Feed</title>
    <link>http://www.simcyp.com/ResearchDevelopment/Publications/Posters/</link>
    <description>Keep updated with Simcyp posters.</description>
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      <title>Tucker GT, Jackson PR, Lennard MS &amp; Woods HF</title>
      <pubDate>Wed, 1 Aug 1990 00:00:00 GMT</pubDate>
      <description>Pharmacokinetic-pharmacogenetic modeling – a basis for the display and detection of polymorphisms in drug metabolism.
In: &lt;i&gt;Proceedings of European Consensus Conference on Pharmacogenetics.&lt;/i&gt; 
(Eds. Alvan G et al.)
&lt;i&gt;ECSC-EC-EAE&lt;/i&gt; 59-67 Brussels, Luxembourg, 1990. </description>
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      <title>Jackson PR, Tucker GT, Lennard MS &amp; Woods HF</title>
      <pubDate>Wed, 1 Aug 1990 00:00:00 GMT</pubDate>
      <description>Testing for bimodality in frequency distributions of data suggesting polymorphisms of drug metabolism – statistical methods.
In: &lt;i&gt;Proceedings of European Consensus Conference on Pharmacogenetics.&lt;/i&gt;
(Eds. Alvan G et al.)
&lt;i&gt;ECSC-EC-EAE&lt;/i&gt; 43-52, Brussels, Luxembourg, 1990.</description>
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      <title>Tucker GT, Rostami-Hodjegan A &amp; Jackson PR</title>
      <pubDate>Tue, 1 Aug 1995 00:00:00 GMT</pubDate>
      <description>The determination of drug metabolising status in vivo: pharmacokinetic and statistical issues. &lt;br&gt;In: &lt;i&gt;Advances in Drug Metabolism in Man.&lt;/i&gt;&lt;br&gt; (Eds. Pacifies GM &amp; Fracchia GN)&lt;br&gt;&lt;i&gt;ECSC-EC-EAE&lt;/i&gt; 37-55, Brussels, Luxembourg, 1995. </description>
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      <title>Tucker GT, Rostami-Hodjegan A, Nurminen S and Jackson PR</title>
      <pubDate>Tue, 1 Aug 1995 00:00:00 GMT</pubDate>
      <description>Phenotyping populations: pharmacokinetic and statistical issues.
In: &lt;i&gt;Variability and Specificity in Drug Metabolism.&lt;/i&gt;&lt;br&gt;(Eds. Alvan G, Balant LP, Bechtel PR et al.)&lt;br&gt;&lt;i&gt;ECSC-EC-EAE&lt;/i&gt; 191-203, Brussels, Luxembourg, 1995. </description>
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      <title>Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Fri, 1 Aug 1997 00:00:00 GMT</pubDate>
      <description>Metabolic variability in populations. &lt;br&gt;In: &lt;i&gt;The Population Approach: measuring and managing variability in response, concentration and dose.&lt;/i&gt;&lt;br&gt;&lt;i&gt;ECSC-EC-EAE&lt;/i&gt; 9-13, Brussels, Luxembourg, 1997.  </description>
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      <title>Rostami-Hodjegan A</title>
      <pubDate>Thu, 1 Jul 1999 00:00:00 GMT</pubDate>
      <description>Incorporating variability into prediction of drug-drug interactions: moving from deterministic to a stochastic approach.&lt;br&gt;&lt;i&gt;Mathematics in Medicine Initiative (MiMI), Compartmental Modelling and Pharmacokinetic Analysis&lt;/i&gt;&lt;br&gt;July 20th-22nd 1999, University of Warwick, United Kingdom.</description>
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      <title>Rostami-Hodjegan A, Tooley A &amp; Tucker GT</title>
      <pubDate>Wed, 1 Nov 2000 00:00:00 GMT</pubDate>
      <description>Incorporating interindividual variability into in vitro – in vivo extrapolation.&lt;br&gt;&lt;i&gt;7th EUFEPS Conference&lt;br&gt;Optimising Drug Development: Strategies to Assess Drug Metabolism/Transport Interaction Potential – Towards a Consensus&lt;/i&gt;&lt;br&gt; November 13th-15th 2000, Basel, Switzerland.</description>
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      <title>Yang JS, Rostami-Hodjegan A &amp; Tucker GT </title>
      <pubDate>Sun, 1 Jul 2001 00:00:00 GMT</pubDate>
      <description>Prediction of fluconazole interaction with midazolam and triazolam: Incorporating population variability.
&lt;i&gt;Proceedings of the British Pharmacological Society&lt;/i&gt; 
July 3rd-5th 2001, Clinical Pharmacology Section, University College, Dublin.&lt;br&gt;
Abstract published in: &lt;i&gt;
British Journal of Clinical Pharmacology&lt;/i&gt; A26, 52(4), 484, 2001.</description>
      <link>http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2014595&amp;rendertype=abstract</link>
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      <title>Boyle J, Rostami-Hodjegan A, Ellis SW &amp; Tucker GT</title>
      <pubDate>Sun, 1 Jul 2001 00:00:00 GMT</pubDate>
      <description>Reference values for human microsomal protein per gram of liver.
&lt;i&gt;Proceedings of the British Pharmacological Society&lt;/i&gt; 
July 3rd-5th 2001, Clinical Pharmacology Section, University College, Dublin.&lt;br&gt;
Abstract published in: 
&lt;i&gt;British Journal of Clinical Pharmacology&lt;/i&gt; A10, 52(4), 471, 2001.</description>
      <link>http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2014595&amp;rendertype=abstract</link>
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      <title>Howgate EM, Proctor NJ, Rostami-Hodjegan A &amp; Tucker GT</title>
      <pubDate>Sun, 1 Jun 2003 00:00:00 GMT</pubDate>
      <description>Prediction drug clearance allowing for the influence of P-glycoprotein activity using SIMCYP™.&lt;br&gt;&lt;i&gt;The Proceedings of the 6th Congress of European Association for Clinial Pharmacology and Therapeutics.&lt;/i&gt;&lt;br&gt; 152, 24th-28th June 2003, Istanbul.</description>
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      <title>Moghadamnia AA, Rostami-Hodjegan A, Abdul-Manap R, Wright CE, Morice AH &amp; Tucker GT</title>
      <pubDate>Tue, 1 Jul 2003 00:00:00 GMT</pubDate>
      <description>Physiologically based modelling of inhibition of metabolism to assess the relative potency of drug and metabolite: dextromethorphan vs dextrorphan using quinidine Inhibition.
&lt;i&gt;British Journal of Clinical Pharmacology&lt;/i&gt;
56, 57-67, 2003.</description>
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      <title>Wilson ZE, Rostami-Hodjegan A, Burn JL, Tooley A, Boyle J, Ellis SW &amp; Tucker GT</title>
      <pubDate>Tue, 1 Jul 2003 00:00:00 GMT</pubDate>
      <description>Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver.
&lt;i&gt;British Journal of Clinical Pharmacology&lt;/i&gt;
56, 433-440, 2003.</description>
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      <title>Yang JS, Kjellsson M, Rostami-Hodjegan A &amp; Tucker GT</title>
      <pubDate>Wed, 1 Oct 2003 00:00:00 GMT</pubDate>
      <description>Predicting metabolic drug-drug interactions for oral drugs: the impact of high transient concentrations of inhibitor and substrate during absorption.
&lt;i&gt;European Journal of Pharmaceutical Sciences&lt;/i&gt; 
20, 223-232, 2003.</description>
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      <title>Proctor NJ, Smith CY, Rostami-Hodjegan A &amp; Tucker GT</title>
      <pubDate>Mon, 1 Dec 2003 00:00:00 GMT</pubDate>
      <description>Population clearance prediction of 13 drugs using SIMCYP™.&lt;br&gt;&lt;i&gt;Pharmacologist&lt;/i&gt;
44 (Supplement 1), LB87, 2002.</description>
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      <title>Yang J &amp; Rostami-Hodjegan A</title>
      <pubDate>Sun, 1 Feb 2004 00:00:00 GMT</pubDate>
      <description>Accounting for first pass gut metabolism improves the relationship between lipophilicity and in vivo permeability.&lt;br&gt;&lt;i&gt;LogP 2004: The 3rd Lipophilicity Symposium&lt;/i&gt;&lt;br&gt; February 29th-March 4th 2004, Zurich, Switzerland.</description>
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      <title>Jamei M, Yang J &amp; Rostami-Hodjegan A</title>
      <pubDate>Sun, 29 Feb 2004 00:00:00 GMT</pubDate>
      <description>Inter and intra-individual variability in physiological parameters of gastro-intestinal tract has significant effects on the predicted fraction of dose absorbed.&lt;br&gt;&lt;i&gt;LogP 2004: The 3rd Lipophilicity Symposium&lt;/i&gt; 
February 29th-March 4th 2004, Zurich, Switzerland. </description>
      <link>/UploadedFiles/127/JameiLogP2004.pdf</link>
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      <title>Jamei M</title>
      <pubDate>Wed, 17 Nov 2004 00:00:00 GMT</pubDate>
      <description>Genetic algorithms and their applications in PK/PD data analysis.&lt;br&gt;&lt;i&gt;Pharmacokinetics U.K. 2004&lt;/i&gt; 
November 17th-18th 2004, Holiday Inn, Belfast, Northern Ireland.</description>
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      <title>Jamei M, Yang J, Rostami-Hodjegan A, &amp; Tucker GT</title>
      <pubDate>Fri, 1 Apr 2005 00:00:00 GMT</pubDate>
      <description>Inter- and intra-individual variability in gastro-intestinal physiology has significant effects on the prediction of fraction of dose absorbed (fa).&lt;br&gt;&lt;i&gt;3rd World Conference on Drug Absorption, Transport &amp; Delivery&lt;/i&gt;&lt;/br&gt; April 18th-20th 2005, Barcelona, Spain.</description>
      <link>/UploadedFiles/126/Jameibarcelona.pdf</link>
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      <title>Dickinson GL, Lennard MS, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Wed, 1 Jun 2005 00:00:00 GMT</pubDate>
      <description>The propagation of genetic polymorphism in CYP2C9 into warfarin pharmacokinetics: an integrated model.&lt;br&gt;&lt;i&gt;Pharmaceutical Sciences Fair &amp; Exhibition&lt;/i&gt;&lt;br&gt; June 12th-17th 2005, Nice, France.</description>
      <link>/UploadedFiles/120/DickinsonNice.pdf</link>
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      <title>Heydari A, Rowland-Yeo K, Lennard MS, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Wed, 1 Jun 2005 00:00:00 GMT</pubDate>
      <description>The impact of study design on the estimation of parameters describing mechanism-based enzyme inhibition.&lt;br&gt;&lt;i&gt; Pharmaceutical Sciences Fair &amp; Exhibition&lt;/i&gt;&lt;br&gt; June 12th-17th 2005, Nice, France. </description>
      <link>/UploadedFiles/121/Heydaripharmsci.pdf</link>
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      <title>Jamei M, Yang J, Rostami-Hodjegan A &amp; Tucker GT </title>
      <pubDate>Wed, 1 Jun 2005 00:00:00 GMT</pubDate>
      <description>Genetic algorithms and their applications in PK/PD data analysis. &lt;i&gt;Pharmaceutical Sciences Fair &amp; Exhibition&lt;/i&gt;&lt;br&gt; June 12th-17th 2005, Nice, France.</description>
      <link>/UploadedFiles/118/Jameipharmsci.pdf</link>
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      <title>Howgate EM, Rowland-Yeo K, Proctor NJ, Rostami-Hodjegan A</title>
      <pubDate>Wed, 1 Jun 2005 00:00:00 GMT</pubDate>
      <description>Incorporation of inter-individual variability into the prediction of in vivo&lt;br&gt;drug clearance.&lt;br&gt;&lt;i&gt;Pharmaceutical Sciences Fair &amp; Exhibition&lt;/i&gt;&lt;br&gt; June 12th-17th 2005, Nice, France.</description>
      <link>/UploadedFiles/119/Howgatepharmsci.pdf</link>
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      <title>Wilson ZE, Ellis SW, Edwards RJ, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Wed, 1 Jun 2005 00:00:00 GMT</pubDate>
      <description>Implications of the disparity in relative holo:apo-protein contents of different standards used for immuno-quantification of hepatic P450 3A4 (CYP3A4).&lt;br&gt;&lt;i&gt;Pharmaceutical Sciences Fair &amp; Exhibition&lt;/i&gt;&lt;br&gt; June 12th-17th 2005, Nice, France.</description>
      <link>/UploadedFiles/124/wilsonpharmsci.pdf</link>
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      <title>Ghanbari F, Rowland-Yeo K, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Wed, 1 Jun 2005 00:00:00 GMT</pubDate>
      <description>A critical evaluation of the experimental design in reports of mechanism based inhibition (MBI) studies and the assessment of their implication for in vitro - in vivo extrapolation (IVIVE).&lt;br&gt;&lt;i&gt; Pharmaceutical Sciences Fair &amp; Exhibition&lt;/i&gt;&lt;br&gt; June 12th-17th 2005, Nice, France.</description>
      <link>/UploadedFiles/125/yeopharmsci.pdf</link>
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      <title>Lei Y, Wilson ZE, Crewe KH, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Wed, 1 Jun 2005 00:00:00 GMT</pubDate>
      <description>Inter-individual variability in the catalytic activity of CYP3A4 per unit of&lt;br&gt;enzyme (kcat).&lt;br&gt;&lt;i&gt;Pharmaceutical Sciences Fair &amp; Exhibition&lt;/i&gt;&lt;br&gt; June 12th-17th 2005, Nice, France.</description>
      <link>/UploadedFiles/122/leipharmsci.pdf</link>
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      <title>Shiran MR, Proctor NJ, Howgate EM, Rowland-Yeo K, Tucker GT, Rostami-Hodjegan A</title>
      <pubDate>Wed, 1 Jun 2005 00:00:00 GMT</pubDate>
      <description>Prediction of xenobiotic clearance in humans: in vitro - in vivo extrapolation (IVIVE) vs allometric scaling (AS).&lt;br&gt;&lt;i&gt;Pharmaceutical Sciences Fair &amp; Exhibition&lt;/i&gt;&lt;br&gt; June 12th-17th 2005, Nice, France.</description>
      <link>/UploadedFiles/123/Shiranpharmsci.pdf</link>
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      <title>Dickinson GL, Lennard MS, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Tue, 1 Nov 2005 00:00:00 GMT</pubDate>
      <description>Simulations to assess the propagation of the impact of genetic polymorphism&lt;br&gt;in CYP enzymes into PK and PD outcomes: warfarin and dextromethorphan&lt;br&gt;as examples.
&lt;i&gt;AAPS Annual Meeting &amp; Exposition&lt;/i&gt;&lt;br&gt;November 6th-10th 2005, Nashville, Tennessee, USA.</description>
      <link>/UploadedFiles/117/DickinsonAAPS.pdf</link>
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      <title>Barter ZE, Burns JL, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Sun, 1 Jan 2006 00:00:00 GMT</pubDate>
      <description>Values of human hepatocellularity per gram of liver and associated variability for use in the prediction of human in vitro metabolic clearance.&lt;br&gt;&lt;i&gt;Hepatocyte User Group (HUG) Meeting&lt;/i&gt;&lt;br&gt; January 26th-27th 2006, Copenhagen, Denmark.</description>
      <link>/UploadedFiles/116/BarterHUG.pdf</link>
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      <title>Turner DB, Rostami-Hodjegan A, Tucker GT &amp; Rowland-Yeo K</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>Prediction of non-specific hepatic microsomal binding from readily available physicochemical properties.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/112/DavidISSX2006.pdf</link>
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      <title>Dickinson GL, Lennard MS, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>The propagation of genetic polymorphism in CYP2C9 into tolbutamide pharmacokinetics: assessment using an intergrated model.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/111/DickinsonISSX2006.pdf</link>
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      <title>Ozdemir M, Crewe HK, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>The impact of dose-staggering on the inhibitory effect of ketoconazole on midazolam clearance, and its prediction using physiologically-based pharmacokinetic modelling.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/113/CreweISSX2006.pdf</link>
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      <title>Almond LM, Rowland-Yeo K, Howgate EM, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>Prediction of the oral clearance of S-warfarin in CYP2C9 genotypes from in vitro enzyme kinetic data.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/115/AlmondISSX2006.pdf</link>
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      <title>Barter ZE, Crewe KH, Harlow JR, Lei Y, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>Differences in cytochrome P450 (CYP3A4) expression alone do not explain inter-individual variability in CYP3A mediated hepatic testosterone 6ß hydroxylase (TST6ßOH) activity.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt;  June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/114/BarterISSX2006.pdf</link>
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      <title>Heydari A, Rowland-Yeo K, Lennard MS, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>Predicting drug interactions with selective serotonin reuptake Inhibitors (SSRIs): impact of non-specific binding and active uptake.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/110/HeydariISSX2006.pdf</link>
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      <title>Van LM, Hammond C, Swales J, Wilson C, Rostami-Hodjegan A &amp; Hargreaves JA</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>Estimation of the kinetic parameters of mechanism-based inhibition of CYP2D6 by methylenedioxymethamphetamine (MDMA) in cryopreserved human hepatocytes.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/105/VanISSX2006hep.pdf</link>
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      <title>Yang J, Tucker GT, &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>In-vitro stability of human recombinant cytochrome P450 enzymes.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/104/YangISSX2006.pdf</link>
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      <title>Rowland-Yeo K, Jamei M, Yang J, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>Prediction of the inhibitory effects of ketaconazole and fluconazole on midazolam and zolpidem clearance from in vitro data using physiologically-based pharmacokinetic modelling.&lt;br&gt;&lt;i&gt;In Vitro Stability of Human Recombinant Cytochrome P450 Enzymes&lt;/i&gt;&lt;br&gt;&lt;i&gt;9th International Conference on Drug-Drug Interactions&lt;/i&gt;&lt;br&gt; June 20th-21st 2006, Seattle, WA, USA.</description>
      <link>/UploadedFiles/103/DDIKRY.pdf</link>
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      <title>Van LM, Rowland-Yeo K, Lennard MS, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>Mechanism-based inactivation of CYP2D6 by methylenedioxymethamphetamine (MDMA): differences between expressed enzyme systems and human liver microsomes.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/106/VanISSX2006.pdf</link>
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      <title>Jamei M, Rostami-Hodjegan A &amp; Tucker GT</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>Co-operativity in the in vitro kinetics of cytochrome P450 (CYP) mediated drug metabolism will have minimal impact on in vivo metabolic clearance.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/109/JameiISSX2006.pdf</link>
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      <title>Johnson TN, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>Modelling of the age related changes of human CYP enzymes for predicting drug disposition in neonates, infants and children.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/108/JohnsonISSX2006.pdf</link>
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      <title>Perrett HF, Barter ZE, Edwards RJ, Lennard MS, Rostami-Hodjegan A &amp; Tucker GT</title>
      <pubDate>Thu, 1 Jun 2006 00:00:00 GMT</pubDate>
      <description>The use of recombinantly expressed standards for immuno-quantification of hepatic CYP3A5 can result in an underprediction of CYP3A5 abundance.&lt;br&gt;&lt;i&gt;9th European ISSX Meeting&lt;/i&gt;&lt;br&gt; June 4th-7th 2006, Manchester, UK.</description>
      <link>/UploadedFiles/107/PerrettISSX2006.pdf</link>
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      <title>Dickinson GL, Lennard MS, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Fri, 1 Sep 2006 00:00:00 GMT</pubDate>
      <description>Assessing the propagation of CYP2C9 polymorphism into the PK/PD of warfarin using clinical trial simulations (CTS).&lt;br&gt;&lt;i&gt;35th Annual Meeting of American College of Clinical Pharmacology&lt;/i&gt; 
September 17th-19th 2006, Cambridge, Massachusetts.&lt;br&gt;
Abstract published in: 
&lt;i&gt;Journal of Clinical Pharmacology&lt;/i&gt; A28, 46(9), 1067, 2006.</description>
      <link>/UploadedFiles/98/DickinsonACCP.pdf</link>
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      <title>Almond LM, Rowland-Yeo K, Howgate EM, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Fri, 1 Sep 2006 00:00:00 GMT</pubDate>
      <description>Utility of data from recombinant expressed genetic variants of CYPs in predicting the influence of genotype on in vivo drug kinetics - the case for S-Warfarin.&lt;br&gt;&lt;i&gt;35th Annual Meeting of American College of Clinical Pharmacology&lt;/i&gt;
September 17th-19th 2006, Cambridge, Massachusetts.&lt;br&gt;
Abstract published in: 
&lt;i&gt;Journal of Clinical Pharmacology&lt;/i&gt; A27, 46(9), 1067, 2006.</description>
      <link>/UploadedFiles/97/AlmondACCP.pdf</link>
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      <title>Johnson TN, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Fri, 1 Sep 2006 00:00:00 GMT</pubDate>
      <description>Prediction of metabolic drug clearance in pediatric subjects and its sensitivity to different models for the development of CYP enzymes.&lt;br&gt;&lt;i&gt;35th Annual Meeting of American College of Clinical Pharmacology&lt;/i&gt; 
September 17th-19th 2006, Cambridge, Massachusetts.&lt;br&gt;
Abstract published in: 
&lt;i&gt;Journal of Clinical Pharmacology&lt;/i&gt; A40, 46(9), 1070, 2006.</description>
      <link>/UploadedFiles/99/JohnsonACCP.pdf</link>
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      <title>Ozdemir M, Crewe KH, Tucker GT &amp; Rostami-Hodjegan A </title>
      <pubDate>Fri, 1 Sep 2006 00:00:00 GMT</pubDate>
      <description>The impact of dose-staggering on the inhibitory effect of ketoconazole on midazolam clearance, and its prediction using PBPK modelling.&lt;br&gt;&lt;i&gt;35th Annual Meeting of American College of Clinical Pharmacology&lt;/i&gt;
September 17th-19th 2006, Cambridge, Massachusetts.&lt;br&gt;
Abstract published in: 
&lt;i&gt;Journal of Clinical Pharmacology&lt;/i&gt; A18, 46(9), 1065, 2006.</description>
      <link>/UploadedFiles/102/CreweACCP.pdf</link>
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      <title>Barter ZE, Rowland-Yeo K, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Fri, 1 Sep 2006 00:00:00 GMT</pubDate>
      <description>A meta-analysis of CYP3A4 abundance in human liver: use of different standards contributes to apparent heterogeneity in reported values.&lt;br&gt;&lt;i&gt;35th Annual Meeting of American College of Clinical Pharmacology&lt;/i&gt; 
September 17th-19th 2006, Cambridge, Massachusetts.&lt;br&gt;
Abstract published in: 
&lt;i&gt;Journal of Clinical Pharmacology&lt;/i&gt; A82, 46(9), 1080, 2006.</description>
      <link>/UploadedFiles/101/KRYACCP.pdf</link>
    </item>
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      <title>Barter ZE, Tucker GT, Rostami-Hodjegan A, Rowland-Yeo K &amp; Howgate EM</title>
      <pubDate>Sun, 1 Oct 2006 00:00:00 GMT</pubDate>
      <description>Prediction of the oral clearance of midazolam using in vitro data from recombinantly expressed enzymes and inter system extrapolation factors.&lt;br&gt;
Abstract published in:
&lt;i&gt;Drug Metabolism Reviews&lt;/i&gt; A71, 38(S2), 41, 2006.</description>
      <link>/UploadedFiles/95/BarterPuertoRico.pdf</link>
    </item>
    <item>
      <title>Almond LM, Rowland-Yeo K, Dickinson GL, Howgate EM, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Sun, 1 Oct 2006 00:00:00 GMT</pubDate>
      <description>Prediction of the oral clearance of tolbutamimde in individuals with different CYP2C9 genotypes using in vitro enzyme kinetic data.&lt;br&gt;&lt;i&gt;14th North American ISSX Meeting&lt;/i&gt;&lt;br&gt; October 22nd-26th 2006, Rio Grande, Puerto Rico.</description>
      <link>/UploadedFiles/96/AlmondPuertoRico2006.pdf</link>
    </item>
    <item>
      <title>Jamei M, Finnoy AL, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Wed, 2 May 2007 00:00:00 GMT</pubDate>
      <description>Bias in estimates of metabolic constants when applying the Michaelis-Menten equation to drugs exhibiting atypical enzyme kinetics.&lt;br&gt;&lt;i&gt;Pharmaceutical Sciences World Congress (PSWC 2007)&lt;br&gt;Optimising Drug Therapy: An Imperative for World Health&lt;/i&gt;&lt;br&gt; 22nd-25th April 2007, Amsterdam, Netherlands. </description>
      <link>/UploadedFiles/152/Masoud Jamei PSWC 2007.pdf</link>
    </item>
    <item>
      <title>Yang J, Jamei M, Rowland Yeo K, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Wed, 2 May 2007 00:00:00 GMT</pubDate>
      <description>Theoretical assessment of a new experimental protocol for determining kinetic values describing mechanism (time) -based enzyme inhibition.&lt;br&gt;&lt;i&gt;Pharmaceutical Sciences World Congress (PSWC 2007)&lt;br&gt;Optimising Drug Therapy: An Imperative for World Health&lt;/i&gt;&lt;br&gt; 22nd-25th April 2007, Amsterdam, Netherlands.</description>
      <link>/UploadedFiles/153/PSWC2007_Amsterdam_Yang 2.pdf</link>
    </item>
    <item>
      <title>Lisa Almond, Karen Rowland Yeo, Eleanor Howgate, Geoffrey T Tuckerand Amin Rostami-Hodjegan</title>
      <pubDate>Wed, 2 May 2007 00:00:00 GMT</pubDate>
      <description>Mechanistic Prediction of HIV Drug-Drug Interactions in Virtual Populations from in vitro Enzyme Kinetic Data: Ritonavir and Saquinavir.</description>
      <link>/UploadedFiles/154/Lisa_Almond_2007_Budapest_SQVr_finalised.pdf</link>
    </item>
    <item>
      <title>Rowland-Yeo K, Jamei M, Yang J, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 24 May 2007 00:00:00 GMT</pubDate>
      <description>Prediction of in vivo drug interactions from in vitro enzyme kinetic data: time-based versus steady state simulations.&lt;br&gt;&lt;i&gt;Pharmaceutical Sciences World Congress (PSWC 2007)&lt;br&gt;Optimising Drug Therapy: An Imperative for World Health&lt;/i&gt;&lt;br&gt; 22nd-25th April 2007, Amsterdam, Netherlands.</description>
      <link>/UploadedFiles/155/PSWC2007 KRY.pdf</link>
    </item>
    <item>
      <title>Yang J, Jamei M, Rowland-Yeo K, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Mon, 25 Jun 2007 00:00:00 GMT</pubDate>
      <description>Comparison of the “well-stirred” gut and the “QGut” models for predicting intestinal first-pass metabolism.&lt;br&gt;&lt;i&gt;4th World Conference on Drug Absorption, Transport and Delivery&lt;br&gt;(4th WCDATD)&lt;/i&gt;&lt;br&gt; June 20th-22nd 2007, Kanazawa, Japan.</description>
      <link>/UploadedFiles/168/Jiansong Yang Qgut WCDATD2007 Japan.pdf</link>
    </item>
    <item>
      <title>Jamei M, Yang J, Turner D, Rowland-Yeo K, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Mon, 25 Jun 2007 00:00:00 GMT</pubDate>
      <description>A novel physiologically-based mechanistic model for predicting oral drug absorption: the advanced dissolution, absorption, and metabolism (ADAM) model.&lt;br&gt;&lt;i&gt;4th World Conference on Drug Absorption, Transport and Delivery&lt;br&gt;(4th WCDATD)&lt;/i&gt;&lt;br&gt; June 20th-22nd 2007, Kanazawa, Japan.</description>
      <link>/UploadedFiles/167/Masoud Jamei WCDADTD Japan.pdf</link>
    </item>
    <item>
      <title>Perrett HP, Barter ZE, Lennard MS, Tucker GT, Rostami-Hodjegan A</title>
      <pubDate>Mon, 25 Jun 2007 00:00:00 GMT</pubDate>
      <description>Assessing the relevance of genetic polymorphism in CYP3A5 in the kinetics of midazolam and tacrolimus: The importance of adequate study size.</description>
      <link>/UploadedFiles/170/Perrett et al., Pharmgen 2007-2.pdf</link>
    </item>
    <item>
      <title>Perrett HP, Barter ZE, Lennard MS, Tucker GT, Rostami-Hodjegan A</title>
      <pubDate>Mon, 25 Jun 2007 00:00:00 GMT</pubDate>
      <description>The impact of genetic polymorphism in CYP3A5 on the pharmacokinetics of the mixed CYP3A4/5 substrates midazolam and tacrolimus assessed by clinical trial simulation (CTS).</description>
      <link>/UploadedFiles/169/Perrett et al., Pharmgen 2007-1.pdf</link>
    </item>
    <item>
      <title>Barter ZE, Crewe KH, Rowland-Yeo K, Tucker GT, Rostami-Hodjegan A</title>
      <pubDate>Thu, 20 Sep 2007 00:00:00 GMT</pubDate>
      <description>Experimental considerations in determining Inter System Extrapolation Factors required for prediction of human drug clearance from recombinantly expressed enzymes. DMDG Open Meeting, Cambridge, UK</description>
      <link>/UploadedFiles/176/Barter DMDG -FINAL.pdf</link>
    </item>
    <item>
      <title>Polak S, Jamei M, Turner D, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 4 Oct 2007 00:00:00 GMT</pubDate>
      <description>Impact of variability in estimates of drug diffusion coefficient on the prediction of fraction absorbed from the gut (fa) using the ADAM model (Simcyp v7.1).&lt;br&gt;&lt;i&gt;EUFEPS &amp; COST B25 Conference on Bioavailability and Bioequivalence:&lt;br&gt; Focus on Physiological Factors and Variability.&lt;/i&gt;&lt;br&gt; October 1st-2nd 2007, Athens, Greece.</description>
      <link>/UploadedFiles/177/EUFEPS_BA-BE_2007_Athens_diffusion_coeff_poster_small.pdf</link>
    </item>
    <item>
      <title>Turner D, Jamei M, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 11 Oct 2007 00:00:00 GMT</pubDate>
      <description>Supersaturation properties of poorly soluble weak bases are key factors in determining oral drug absorption: a simulation study of nifedipine using the ADAM model (Simcyp v7.1).&lt;br&gt;&lt;i&gt;EUFEPS &amp; COST B25 Conference on Bioavailability and Bioequivalence:&lt;br&gt;Focus on Physiological Factors and Variability.&lt;/i&gt;&lt;br&gt; October 1st-2nd 2007, Athens, Greece.</description>
      <link>/UploadedFiles/178/David_Turner_EUFEPS_Athens_2007 Final.pdf</link>
    </item>
    <item>
      <title>Johnson TN, Boussery K, Polak S, Tucker GT &amp; Rostami-Hodjegan, A</title>
      <pubDate>Fri, 11 Apr 2008 00:00:00 GMT</pubDate>
      <description>Mechanistic models of human pharmacokinetics to predict the effects of liver cirrhosis on the clearance of nine drugs.&lt;br&gt;&lt;i&gt;American Conference on Pharmacometrics.&lt;/i&gt;&lt;br&gt; March 9th-12th 2008, Tucson, Arizona, USA.</description>
      <link>/UploadedFiles/211/Trevor_Sebastian_ACoP.pdf</link>
    </item>
    <item>
      <title>Neuhoff S, Yang J, Jamei M, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 22 May 2008 00:00:00 GMT</pubDate>
      <description>Simulation of the effect of P-glycoprotein on drug absorption in the human gastrointestinal tract.&lt;br&gt;&lt;i&gt;10th European ISSX Meeting.&lt;/i&gt;
May 18th -21st  2008, Vienna, Austria.</description>
      <link>/UploadedFiles/216/2008 05_ISSX Vienna_Poster_ADAM_Pgp_landscape - final.pdf</link>
    </item>
    <item>
      <title>Neuhoff S, Barter ZE, Rowland-Yeo K, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 22 May 2008 00:00:00 GMT</pubDate>
      <description>In  vitro-in vivo extrapolation of the clearance of drugs by glucuronidation: Scaling factors for recombinant UGT1A1 data.&lt;br&gt;&lt;i&gt;10th European ISSX Meeting.&lt;/i&gt;
May 18th -21st  2008, Vienna, Austria.</description>
      <link>/UploadedFiles/217/2008 05_ISSX Vienna_Poster_Phase II_UGT1A1_landscape.pdf</link>
    </item>
    <item>
      <title>Yang J, Liao M, Shou M, Jamei M, Rowland-Yeo K, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Thu, 22 May 2008 00:00:00 GMT</pubDate>
      <description>Cytochrome P450 turnover: methods for determining rates and implications for the prediction of drug interactions.&lt;br&gt;&lt;i&gt;2nd Asian Pacific ISSX Meeting.&lt;/i&gt; 
May 11th-13th 2008, Shanghai, China.</description>
      <link>/UploadedFiles/218/ISSX Shanghai Yang 2008.pdf</link>
    </item>
    <item>
      <title>Johnson TN, Boussery K, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Fri, 23 May 2008 00:00:00 GMT</pubDate>
      <description>Prediction of the increased exposure to drugs in liver cirrhosis: a systems biology approach integrating prior information on disease with &lt;i&gt;in vitro&lt;/i&gt; data on drug disposition.&lt;i&gt;
10th European ISSX Meeting.&lt;/i&gt;&lt;br&gt;May 18th–21st 2008, Vienna, Austria.</description>
      <link>/UploadedFiles/219/ISSX Vienna Trevor 2008.pdf</link>
    </item>
    <item>
      <title>Polak S, Jamei M, Turner DB, Yang J, Neuhoff S, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Fri, 23 May 2008 00:00:00 GMT</pubDate>
      <description>Prediction of the in vivo behaviour of modified release formulations of metoprolol from in vitro dissolution profiles using the ADAM model (Simcyp®V8).&lt;br&gt;&lt;i&gt;10th European ISSX Meeting.&lt;/i&gt;
May 18th–21st 2008, Vienna, Austria.</description>
      <link>/UploadedFiles/220/ISSX Vienna Sebastian 2008.pdf</link>
    </item>
    <item>
      <title>Crewe HK, Barter ZE, Rowland-Yeo K, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Fri, 20 Jun 2008 00:00:00 GMT</pubDate>
      <description>Comparison of the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9: determination of inter system extrapolation factors&lt;i&gt;
10th European ISSX Meeting.&lt;/i&gt; 
May 18th–21st 2008, Vienna, Austria.</description>
      <link>/UploadedFiles/221/Crewe et al. 2008  ISSX-10 Vienna 05-08 (ISEF liver CYP2C9).pdf</link>
    </item>
    <item>
      <title>Perrett HF, Barter ZE, Lennard MS, Tucker GT &amp; Rostami-Hodjegan A</title>
      <pubDate>Fri, 20 Jun 2008 00:00:00 GMT</pubDate>
      <description>What is the level of expression of CYP2D6 in human liver? Influence of different calibration standards of the estimation of CYP2D6 abundance.
&lt;i&gt;10th European ISSX Meeting.&lt;/i&gt; 
May 18th–21st 2008, Vienna, Austria.</description>
      <link>/UploadedFiles/222/Perrett et al. 2008  ISSX-10 Vienna 05-08 (abundance CYP2D6 liver).pdf</link>
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